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    The drug is often taken once a day, even though the dosage amount can vary greatly slightly from patient to patient. Dosing of Actos is relatively simple for the reason that one pill each day is required and might be taken with or without a meal. However, the not so good news is patients who took pioglitazone were more prone to own fluid retention that can end in serious heart failure. Any from the above mentioned unwanted side effects should be reported to your physician or doctor immediately.

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